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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PARP1
All Species:
22.73
Human Site:
S140
Identified Species:
50
UniProt:
P09874
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P09874
NP_001609.2
1014
113084
S140
E
K
G
Q
V
R
L
S
K
K
M
V
D
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090751
1014
112883
S140
E
K
G
Q
V
R
L
S
K
K
M
L
D
P
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P11103
1013
113081
S140
E
K
G
Q
M
R
L
S
K
K
M
V
D
P
E
Rat
Rattus norvegicus
P27008
1014
112642
S140
E
K
G
Q
M
R
L
S
K
K
M
L
D
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
P26446
1011
113502
S140
E
K
G
Q
I
R
I
S
K
K
M
V
H
P
E
Frog
Xenopus laevis
P31669
998
111108
I140
E
R
P
Q
L
G
M
I
D
R
W
Y
H
P
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P35875
994
113773
T140
D
L
V
R
L
R
K
T
V
Y
D
T
E
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9N4H4
945
107988
R138
K
C
G
Q
N
F
E
R
G
E
I
K
A
H
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002302058
996
111716
S141
M
K
G
E
V
R
I
S
S
K
P
D
G
Q
G
Maize
Zea mays
Q9ZSV1
980
110457
Y145
G
P
K
G
I
P
W
Y
H
A
N
C
F
F
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9ZP54
983
111214
F141
L
K
G
E
V
R
I
F
S
K
P
E
G
P
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.2
N.A.
N.A.
91.9
91.7
N.A.
N.A.
79.1
73
N.A.
N.A.
41.7
N.A.
31.3
N.A.
Protein Similarity:
100
N.A.
99.1
N.A.
N.A.
95.8
95.2
N.A.
N.A.
88.6
84.2
N.A.
N.A.
61.2
N.A.
51.5
N.A.
P-Site Identity:
100
N.A.
93.3
N.A.
N.A.
93.3
86.6
N.A.
N.A.
80
20
N.A.
N.A.
6.6
N.A.
13.3
N.A.
P-Site Similarity:
100
N.A.
100
N.A.
N.A.
100
100
N.A.
N.A.
93.3
53.3
N.A.
N.A.
40
N.A.
33.3
N.A.
Percent
Protein Identity:
41.1
39.3
N.A.
39.4
N.A.
N.A.
Protein Similarity:
59.5
57.5
N.A.
58.3
N.A.
N.A.
P-Site Identity:
40
6.6
N.A.
40
N.A.
N.A.
P-Site Similarity:
53.3
13.3
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
10
0
10
10
37
0
10
% D
% Glu:
55
0
0
19
0
0
10
0
0
10
0
10
10
0
55
% E
% Phe:
0
0
0
0
0
10
0
10
0
0
0
0
10
10
0
% F
% Gly:
10
0
73
10
0
10
0
0
10
0
0
0
19
0
28
% G
% His:
0
0
0
0
0
0
0
0
10
0
0
0
19
10
0
% H
% Ile:
0
0
0
0
19
0
28
10
0
0
10
0
0
0
0
% I
% Lys:
10
64
10
0
0
0
10
0
46
64
0
10
0
0
0
% K
% Leu:
10
10
0
0
19
0
37
0
0
0
0
19
0
0
0
% L
% Met:
10
0
0
0
19
0
10
0
0
0
46
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
10
% N
% Pro:
0
10
10
0
0
10
0
0
0
0
19
0
0
64
0
% P
% Gln:
0
0
0
64
0
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
10
0
10
0
73
0
10
0
10
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
55
19
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
0
% T
% Val:
0
0
10
0
37
0
0
0
10
0
0
28
0
10
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
10
0
10
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _